Stay ahead of the competition with custom-built, automated data processing workflows for your targets. We specialize in creating efficient and tailored workflows that can be seamlessly executed from the command line, requiring minimal user inputs. Our automated data processing solutions are designed to accelerate the generation of high-resolution maps of your ligand-bound targets. We have achieved high resolution maps as low as 2.1 Å from micrographs in as little as 24 hours!
Provided adequate instrument access, multiple ligand bound structures can be determined per week - facilitating high-throughput structure-based drug design.
✔️ Our automated workflows are written in Python for ease of use
✔️ Can be tailored to each specific target, providing easy scalability
✔️ Encompass entire workflows from motion correction to particle polishing
✔️ Allow use of multiple software suites to get the most out of your data
Cryo-EM has revolutionized the field of structural biology by enabling the visualization of biomolecules at near-atomic resolution. However, biological macromolecules often exist in dynamic states, adopting multiple conformations that are essential for their function. With the power of cryo-EM, we can help you unravel the conformational heterogeneity of your targets to decipher cryptic pockets or rare conformations that can aid in your structure-based drug design.
Effective project management is crucial in the rapidly evolving field of cryo-electron microscopy (cryo-EM) and structural biology, especially when infrastructure may be limited. We understand the unique challenges faced by startups and work closely with them to develop tailored project plans, establish milestones, and allocate their resources efficiently. With our deep knowledge of cryo-EM workflows and data processing techniques, we help these companies navigate the complexities of data acquisition, processing, and analysis. Furthermore, we assist in setting up the required infrastructure, recommending and implementing the necessary hardware, software, and data management systems. By providing end-to-end project management solutions, we enable newly starting companies to accelerate their research, enhance productivity, and achieve their scientific goals in the most efficient manner possible.
We understand that sample purification and grid preparation are critical steps in obtaining high-quality cryo-EM data. While we don't directly perform sample or grid preparation, we collaborate closely with your scientists and grid preparers to achieve the best results for your research. Our expertise lies in providing tailored guidance, optimizing protocols, and offering strategic advice throughout the sample purification and grid preparation process. By leveraging our deep understanding of cryo-EM sample preparation, we help identify and address potential challenges, fine-tune experimental conditions, and ensure optimal grid quality. Through this collaborative approach, we enable you to obtain grids that are highly suited for cryo-EM imaging, leading to improved resolution and enhanced structural insights.